Clomid binds selectively to certain estrogen receptors. The hypothalamus “reads” this binding as low estrogen levels and signals the pituitary to produce more LH and FSH. This in turn results in the production of testosterone. Essentially Clomid tricks the body of our research rats into perceiving low levels of estrogen. In male rat subjects the primary source of estrogen is from the aromatization of testosterone. In order to increase the perceived low estrogen levels the bodies’ only solution is to force the production of more testosterone.
Clomid has been shown in studies to effectively and efficiently restore HPTA function from essentially zero to clinically normal levels in under a 30 day period. The combination of clomid and nolvadex (tamox) has been shown in studies to do so even more effectively.
Refs:
*Clomiphene Citrate Effects on Testosterone/Estrogen Ratio in
Male Hypogonadism
Ahmad Shabsigh, MD, Young Kang, MD, Ridwan Shabsign, MD, Mark Gonzalez, MD,
G0ary Liberson, MD, Harry Fisch, MD, and Erik Goluboff, MD
Department of Urology, NY Presbyterian Medical Center, New York, NY, USA
DOI: 10.1111/j.1743-6109.2005.00075.x
*Med Hypotheses. 2009 Jun;72(6):723-8. Epub 2009 Feb 23. Anabolic steroid-induced hypogonadism--towards a unified hypothesis of anabolic steroid action. Tan RS, Scally MC. Source HPT/Axis Inc., 1660 Beaconshire Road, Houston, TX 77077, USA.
Clomid has been shown in studies to effectively and efficiently restore HPTA function from essentially zero to clinically normal levels in under a 30 day period. The combination of clomid and nolvadex (tamox) has been shown in studies to do so even more effectively.
Refs:
*Clomiphene Citrate Effects on Testosterone/Estrogen Ratio in
Male Hypogonadism
Ahmad Shabsigh, MD, Young Kang, MD, Ridwan Shabsign, MD, Mark Gonzalez, MD,
G0ary Liberson, MD, Harry Fisch, MD, and Erik Goluboff, MD
Department of Urology, NY Presbyterian Medical Center, New York, NY, USA
DOI: 10.1111/j.1743-6109.2005.00075.x
*Med Hypotheses. 2009 Jun;72(6):723-8. Epub 2009 Feb 23. Anabolic steroid-induced hypogonadism--towards a unified hypothesis of anabolic steroid action. Tan RS, Scally MC. Source HPT/Axis Inc., 1660 Beaconshire Road, Houston, TX 77077, USA.
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